PRKN and Alzheimer disease: In the motor neuron of fALS-linked SOD1G93A mice and the axons of AD-related cortical neurons from mutant human APP-expressing transgenic mice, impaired mitochondria are removed via the bulk release of SNPH cargo vesicles, which are mitochondria-derived and Parkin-independent, promoting mitochondria transport (Lin et al., 2017a).