In addition, glycolytic defects in oligodendrocytes induce axon degeneration in both AD mice and patients via the Drp1-hexokinase 1-NLRP3 (NLR family pyrin domain containing 3) signaling axis, which is considered to be a therapeutic target (Yan et al., 2020a; Zhang et al., 2020). The gene discussed is NLRP3; the disease is Alzheimer disease.