Microglia-mediated neuroinflammation is considered a major AD-inducing factor (Tejera and Heneka, 2016; Hansen et al., 2018), and SELENOK overexpression significantly increases the Ca2+ level and IP3R expression and promotes the migration and phagocytosis of microglia to regulate neuroimmunity and neuroinflammation in the brain (Meng et al., 2019). The gene discussed is SELENOK; the disease is Alzheimer disease.