CTSD and neuroblastoma: Proteins glucose-6-phosphate isomerase (GPI), VPS41 (involved in lysosomal biogenesis and Golgi-vacuole trafficking), and cathepsin D were identified in a screen as a protector against α-synuclein-mediated dopaminergic neuronal degeneration by RNAi in C. elegans and then verified in Drosophila, mice, and human neuroblastoma cells (Hamamichi et al., 2008; Qiao et al., 2008; Ruan et al., 2010; Knight et al., 2014).