The genetic etiologies of DBA/1&2, Cacna1aS218L, RyR2R176Q, Lmx1bf/f/p, and Kcna1 KO mice are either unknown, identified from non-epilepsy patient populations, or are manipulations that lead to loss of an entire cell population, receptor subtypes, or ion channels, which are not known to occur in epilepsy patients. Here, KCNA1 is linked to epilepsy.