SCN8A and Encephalopathy: SCN8A encephalopathy is a severe genetic epilepsy syndrome and neurodevelopmental disorder characterized by refractory seizures, cognitive and motor dysfunction, and a substantial risk for SUDEP (Veeramah et al., 2012; de Kovel et al., 2014; Estacion et al., 2014; Ohba et al., 2014; Blanchard et al., 2015; Larsen et al., 2015; Gardella et al., 2018; Zaman et al., 2019).