Thus, upon anti-PD1 immunotherapy in NASH mice, CD8+PD1+ T cells accumulated to high numbers in the liver, revealing a resident-like T cell character with increased expression of CD44, CXCR6, EOMES and TOX and low levels of CD244 expression, but lacking expression of TCF1/TCF7, CD62L, TBET, and CD127 (Extended Data Fig. 6p–u). This evidence concerns the gene CXCR6 and metabolic dysfunction-associated steatohepatitis.