PON1 and coronary artery disorder: On the other hand, the PON1 rs662 G (192R) and the PON1 rs854560 A (L55) alleles, which are related to the high activity PON1 isoform, were also found to be associated with atherogenic serum lipid profile46 and common in atherosclerotic diseases (CHD, ICS) in the general population47,48.