Using these top 20 genes for pathway annotation gave a clear picture of cancer-related KEGG pathways, i.e.: KEGG Pathways in Cancer (FDR = 2.94e−44) was the top enriched pathway, followed by Hepatitis B (FDR = 2.51e−39) and Cell cycle (FDR = 2.3e−38). This evidence concerns the gene PPIB and cancer.