Given the close similarity between their biochemical features and the reported functional redundancies among NEDD4 family members, these data suggest that several NEDD4 family E3 ligases might participate in regulating COVID-19 egression via direct interaction with and ubiquitination of the SARS-CoV-2 S protein and associated proteins (Fig. 5G), but their potential complementary roles, as well as their biological and functional impacts in COVID-19 biology await further investigation. This evidence concerns the gene NEDD4 and COVID-19.