PFKFB3 and neoplasm: To further examine the effect of lncRNA H19 on tumor progression and the PFKFB3 gene-mediated glycolysis pathway in vivo, we established a nude mouse transplanted tumor model and used shRNAH19-1720 (named sh-H19) to knockdown the expression of lncRNA H19 in oral CAFs (Fig. 5a).