Mechanistically, lncRNA H19 facilitates the G1/S transition to promote cell proliferation in esophageal squamous cell carcinoma,45 and miR-675-5p induced by lncRNA H19 suppressed p53 protein, leading to increased cell proliferation in non-small cell lung cancer.46 Similarly, in this study, using a CCK-8 assay, we found that lncRNA H19 promoted oral CAF proliferative phenotypes. Here, TP53 is linked to esophageal squamous cell carcinoma.