The mature miRNAs miR-675-3p and miR-675-5p, derivatives of lncRNA H19,26 have been found to be involved in cancer development.25 At the RNA level, we found that lncRNA H19 knockdown significantly reduced the expression of miR-675-3p and miR-675-5p (Figs. S3d and 4d). This evidence concerns the gene H19 and cancer.