H19 and cancer: It is generally accepted that cells that show active proliferative capacity prefer glycolysis even when oxygen is present to meet fast growth and proliferation demands, which is known as the “Warburg effect”,42,43 but the roles of lncRNA H19 in affecting the biological hallmarks of CAFs have not been well addressed.44 To date, lncRNA H19 has been reported to sustain cell proliferation in cancer.