LncRNAs mediate glucose metabolism reprogramming in cancer mainly by regulating metabolic enzymes directly and/or by mutual regulation with oncogenes or tumor suppressors indirectly.12 As an emerging hallmark of cancer, metabolic interactions are an important aspect of crosstalk in the tumor stroma,29 and CAF metabolic reprogramming can promote tumor progression.6–8 In this study, we found that lncRNA H19, the first discovered riboregulatory lncRNA, is a potential EMCT candidate with antitumor activity. This evidence concerns the gene H19 and cancer.