Gene profiling in SCs treated with metformin pointed that metformin reduced the pro-inflammatory cytokines expression, mostly regulated by mTOR.40,42 Specifically, SASP such as TNF-α, IL-1β, and IL-6 triggered the upregulation of primary periodontal tissue destruction mediators in diabetes,34 which was markedly decreased by metformin. The gene discussed is IL6; the disease is diabetes mellitus.