SLC2A1 and Hyperglycemia: C57BL/6J mice with STZ-induced diabetes kept for 20 months were used as aged-diabetic model43 because that BLKdb/db mice obtaining uncontrollable hyperglycemia survived only for 10 months.44 Within the limitation of the study, these results implied that GLUT1-mediated macrophage inflammation and SASP response might have vital roles in diabetes-related periodontal lesions.