Co-localization for GLUT1/F4-80/p16 showed widespread triple-positive cells in the periodontal lesions of db/db mice (15.7% vs. 0.9% of normoglycemic mice) (Fig. 3f and Supplementary Fig. S3g), indicating that GLUT1 overexpression might inhibit macrophage cycle and contribute to macrophage inflammation in diabetes-related periodontal lesions. The gene discussed is CDKN2A; the disease is diabetes mellitus.