Finally, decreased SIRT1 and Nrf2 and increased Nur77 levels were observed in the heart of T2D mice, which were normalized with FGF1ΔHBS treatment in the WT-T2D mice, while these effects of FGF1ΔHBS were abrogated in the AMPKα2−/−-T2D mice (Fig. 7h). This evidence concerns the gene NFE2L2 and type 2 diabetes mellitus.