Additionally, astrocytes, which co-exist with GBM cells in the hypoxic microenvironment, were found to release IL-6, -8 and CCL20, which up-regulate HIF-1α in a CCR6/NF-κB signaling-dependent manner and thereby helping GBM cells better adapt to hypoxia (Fig. 1d) [59]. Here, HIF1A is linked to glioblastoma.