Genomic aberrations in neurofibromin 1 (NF1) gene have been reported as one of the major characteristics of the mesenchymal GBM, and NF1 deficiency has been shown to recruit TAMs to the tumor site, indicating that reconstituting functional NF1 may prevent mesenchymal transformation in GBM [155, 161]. The gene discussed is NF1; the disease is glioblastoma.