TP53 and glioblastoma: In 2010, a group of researchers from TCGA built upon this work to identify four transcriptomic subtypes of GBM—proneural, neural, classical and mesenchymal—based on unsupervised transcriptomic analysis of 202 newly diagnosed GBM cases, which showed strong associations with genomic alterations of genes such as TP53, EGFR and NF1 [155].