Chong et al. based on the association of cell surface sialyation with tumor cell invasiveness, investigated the role of ST3GAL1 sialytransferase gene in GBM and found that this is triggered by TGFβ signaling pathway typically in mesenchymal GBM and also regulates gliomagenesis via APC/C-Cdh1-targeted control of FoxM1 protein degradation. This evidence concerns the gene FOXM1 and glioblastoma.