Dumas et al. reported that mTOR-dependent regulation of STAT3 and NF-kB activity in microglia were induced by GBM-initiating cells, which subsequently promote an immunosuppressive microglial phenotype, and that such mTOR activity is most significantly correlated with tumor-associated microglia signatures in the mesenchymal subgroup of GBM [33]. This evidence concerns the gene STAT3 and glioblastoma.