As shown in Tables 1 and 2, the results showed that NRF2 may directly target genes related to fatty acid β-oxidation metabolism (CPT1A and CPT2), mitochondrial respiratory (IDH, IDH2 complex I (NADHFS, NDUFA2, NDUFA5, NDUFA10, NDUFB2), complex II (SDHB), complex IV (COX6A1, COX5A), complex V (ATP5F1B, ATP5B, ATP5FA)), potassium ion channel genes (KCNC3, KCNA7, KCND3, KCNT1, KCNE4), and cardiac hypertrophy (EDN1). The gene discussed is COX5A; the disease is cardiac hypertrophy.