Given these observations, we queried the pathway for candidate targets of TDP-43 mediated translational inhibition and found dlp mRNA to be enriched in TDP-43 complexes (TDP-43WT, Log2FC = 3.62, Padj = 8.32E−57; TDP-43G298S, Log2FC = 4.63, Padj = 2.47E−57) and significantly depleted from ribosomes in the context of TDP-43 proteinopathy (TDP-43WT, Log2FC = −1.03, Padj = 0.027; TDP-43G298S, Log2FC = −0.85, Padj = 0.012, see also Additional file 5: Table S4-1). The gene discussed is TARDBP; the disease is proteostasis deficiencies.