GO term analyses using David 6.8 [42, 43] of mRNAs enriched with both TDP-43WT and TDP-43G298S (Log2FC > 2, Padj < 0.05) highlight neuronal pathways previously linked to TDP-43 such as NMJ development [33] and synaptic growth [23, 99] (Fig. 1e, g, Additional file 1: Table S1-2,3,4) and are consistent with published studies of TDP-43 interacting RNAs in a murine model of TDP-43 proteinopathy [91]. The gene discussed is TARDBP; the disease is proteostasis deficiencies.