TARDBP and proteostasis deficiencies: Here we combined RNA immunoprecipitations (RIP) and translating ribosome affinity purification (TRAP) to identify mRNAs that simultaneously satisfy two criteria: 1) are enriched in TDP-43 complexes and thus have the potential to be regulated by TDP-43, and 2) their association with ribosomes is altered in the context of Drosophila models of TDP-43 proteinopathy, consistent with an effect on translation.