TARDBP and amyotrophic lateral sclerosis: Consistent with dlpOE mitigating TDP-43 induced locomotor defects, dlp knockdown by RNA interference (dlpRNAi) enhanced locomotor deficits in both ALS models based on TDP-43 overexpression (16.9 ± 1.21 s for TDP-43WT dlpRNAi compared to 14.00 ± 0.76 s for TDP-43WT alone, Pvalue = 0.017; 29.30 ± 2.56 s for TDP-43G298S dlpRNAi compared to 16.10 ± 0.73 s for TDP-43G298S alone, Pvalue = 1.9E−4, see Fig. 6b).