Surprisingly, genes related to cytoplasmic translation are enriched in the ALS motor neuron translatomes relative to the RpL10 controls, possibly reflecting a compensatory mechanism whereby degenerating neurons upregulate global translation in response to increased cellular stress or to mitigate cytoplasmic TDP-43′s inhibitory effect on protein synthesis [88]. The gene discussed is RPL10; the disease is amyotrophic lateral sclerosis.