Further substantiating this finding, dlp mRNA was insolubilized in a TDP-43G294A (Fold change = 2.51, Pvalue = 0.034, Fig. 4e) but not in the TDP-43WT CRISPR fly model of ALS in which the endogenous Drosophila TDP-43 (TBPH) gene has been replaced with human TDP-43 [9]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.