TARDBP and amyotrophic lateral sclerosis: GO term analyses of these TDP-43 enriched, TRAP depleted genes using David 6.8 [42, 43] identified pathways that have previously been associated with ALS including GPCR signaling [28, 97], NMJ Development [28, 97], Autophagy [6, 116], ER Organization [112], Immune Response [65] and Oxidation Reduction [95] among others (Fig. 3b–e, 3: Table S3-2,3).