Since tau phosphorylation and aggregation is one of the major causes of neurodegeneration and correlates more closely with dementia status than Aβ deposition does [6], we systemically determined alterations of NVU in the retina using histological and non-invasive imaging and functional tests in two transgenic mouse models of tauopathy (P301S and P301L mice) at different stages of disease progression. The gene discussed is MAPT; the disease is tauopathy.