The 2020 European Society of Pediatric Gastroenterology Hepatology and Nutrition guidelines for celiac disease have allowed a biopsy-free approach in endomysial antibodies positive children with high serum antitransglutaminase (TGA)-IgA titer (> 10 time upper limit of normal), being esophagogastroduodenoscopy still necessary for diagnosis in children with lower title [52]. The gene discussed is CD79A; the disease is celiac disease.