A single tyrosine 641 (Tyr641) in the SET domain of EZH2 is replaced in 7.2% follicular lymphoma (FL) and 21.7% germinal center B-cell-like (GCB) subtype diffuse large B-cell lymphoma (DLBCL) [10]. The gene discussed is EZH2; the disease is diffuse large B-cell lymphoma.