The presence of surface markers CD101 and CD38 has been associated with reduced reprogrammability of high PD-1-expressing tumor-infiltrating CD8 + T cells, a finding with important clinical relevance as these markers can be used to discriminate reprogrammable from non-reprogrammable PD-1 high T cells within the heterogeneous TIL populations [98]. This evidence concerns the gene CD8A and neoplasm.