SLC5A5 and neoplasm: In a very different strategy, OVs coding for the human sodium-iodine symporter (NIS) have been used to enhance the specific intake of [143]I in OV-infected tumor cells [99, 205–207]; OV-NIS are injected several days before [143]I and indirectly mediate the vectorization of the radioelement to tumors neo-expressing NIS.