On the other hand, hypoxia induced release of chemoattractants (such as HIF-1α and HIF-2α) and tumor derived cytokines (such as IL-10, IL-4, and TGF-β) are able to hijack tumor-associated macrophages (TAMs) and tumor-associated dendritic cells (TADCs) functions, resulting in tumor metastasis [13, 14]. This evidence concerns the gene IL10 and neoplasm.