The analysis of the differentially expressed genes to KEGG (Kyoto Encyclopedia of Genes and Genomes) Pathways (https://www.genome.jp/kegg/) identified the cytokine-cytokine receptor interaction pathway as significantly upregulated by EML4-ALK expression in mortal CRL-2097/TR fibroblasts, along with some related and overlapping pathways involving tumor necrosis factor (TNF) or viral infection (Table 1 and Supplementary Table S3). This evidence concerns the gene TNF and viral infectious disease.