GDF15 and metabolic dysfunction-associated steatotic liver disease: In one example, the strong induction of lnc7169 by TCPOBOP may contribute to the hepatoprotective effects of CAR activation on high fat diet-induced non-alcoholic fatty liver disease [99, 100] by increasing expression of the divergently transcribed Gdf15, a stress response cytokine that is induced by inflammation, acute injury and oxidative stress [67].