MMP2 and pachyonychia congenita: Dysregulation of MMPs in PC frequently indicated poor prognosis.[33,42,43] Downregulation of feline sarcoma-related/signal transducer and activator of transcription 3/MMP2 pathway suppressed the metastasis and invasion of PC.[44] Protein kinase D2 stimulated MMP7 and MMP9, leading to the invasion of pancreatic cells.[45]