High expression of MMP28 was regulated by Rac GTPase activating protein 1 and indicated worse prognosis in PC.[46] Our research supplemented the research topic related to the prognostic performance of MMP28 in PC and further validated the conclusion that high expression of MMP28 was associated with unfavorable prognosis in PC. The gene discussed is RACGAP1; the disease is pachyonychia congenita.