In the part of univariate analysis, age, histologic grade, patients with progression, and the expression level of MMP28 served as risk factors for OS in patients with PC, with the corresponding hazard rate (HR) values of 1.030 (95% confidence interval [CI]: 1.003, 1.057) (P = .029), 1.435 (95% CI: 1.064, 1.936) (P = .018), 1.994 (95% CI: 1.101, 3.612) (P = .023), and 1.487 (95% CI: 1.214, 1.821) (P < .001), whereas variables such as histological type (HR: 0.547, P = .003), tumor location (HR: 0.660, P = .034), and radiation therapy (HR: 0.334, P = .007) indicated better prognosis in patients. This evidence concerns the gene MMP28 and pachyonychia congenita.