The protein binds directly to 2 basic components of the TIP60/HAT complex and histone deacetylase complexes: MORF4-related gene on chromosome 15 and MORF4-related gene on chromosome X proteins.[5] MRGBP is frequently amplified in numerous types of cancer, including lung,[6] prostate,[7,8] and pancreatic cancers[9,10]; cutaneous squamous cell carcinoma[11]; and colorectal[12–14] and cervical cancers,[15] and is involved in the regulation of the cell cycle, apoptosis, growth, and invasion.[8,11,13,15] MRGBP may play a biological role as a diagnostic biomarker and anticancer target for tumors. Here, MORF4 is linked to cutaneous squamous cell carcinoma.