FOXP3 plays a direct role in suppressing Th2-like Tregs,[10] and the uncontrolled Th2 immune responses of IPEX not only dominate the autoimmune responses in the target tissues, but also hinder the host from mounting effective and appropriate immune responses to invading microorganisms and exogenous antigens,[11,12] which lead to autoimmune diseases, allergies, and recurrent infections. Here, FOXP3 is linked to immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.