The clinical manifestations of IPEX are variable and laboratory test results including the number of CD4+ FOXP3+ Tregs,[31,32] serum immunoglobulin levels,[33,34] and types of autoantibodies[9,35] are nonspecific; therefore, we have summarized some diagnostic clues from this case and previous literature:. This evidence concerns the gene FOXP3 and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.