Another study assumed the high prevalence of candidemia among patients treated with TCZ can be the consequence of multiple well known risk factors it can be speculated that the suppression of IL-6 response might contribute to this blood infection.[19] Interestingly, previous studies conducted in interleukin-6 deficient mice showed that they were more susceptible to systemic Candida albicans infection, had a decreased survival and an increased fungal load in their organs when compared with IL-6 positive controls.[20,21]. The gene discussed is IL6; the disease is Candidemia.