CHD is the most common chronic disease with the highest mortality in the world, and the process of its occurrence and development is always accompanied by the aggravation of atherosclerosis.[28,29] Studies have proved that PD-L is involved in the pathogenesis of atherosclerosis through immunity.[30–32] Many scholars have investigated the relationship between the expression of PD-L1 in peripheral blood T lymphocytes and CHD, but the results are different and the sample size is small. This evidence concerns the gene CD274 and atherosclerosis.