IGHE and allergic disease: Allergic rhinitis is often induced by weather changes, pollen, animal hair, diet and other allergic factors, the main clinical manifestations are continuous episodes of paroxysmal sneezing, a large number of watery snot, nasal congestion and itching, and some patients have decreased sense of smell, affecting the quality of life.[22] AR is an allergic reaction mediated by IgE under the chemotaxis of various inflammatory cytokines after specific individual contact with antigen.