Currently, the main causes of the anemias that lead to hydrops fetalis are severe alpha-thalassemia, parvovirus infection, and maternal blood transfusion, and so on[2]; while hydrops fetalis due to anemia caused by hereditary spherocytosis (HS), especially that occurring in the neonatal period, is rarely reported.[3–8] Among these reports, Hannah et al[3] and Chonat et al[4] reported 2 cases of hydrops fetalis caused by HS due to an SPTA1 gene mutation, and Gallagher et al[6,7] reported 1 case of hydrops fetalis caused by HS due to a β-hemoglobin abnormality. The gene discussed is SPTA1; the disease is anemia.