However, the spindle tumor component was diffusely strongly positive for vimentin and negative for AE1/AE3 (Fig. 6B), whereas all the tumor cells were negative for neuroendocrine markers and other mesenchymal markers, such as desmin, SMA, myglobin, mygenin, S-100, DOG-1, CD34, CD117 and. The gene discussed is DES; the disease is neoplasm.