The upregulated DEGs including MMP8/9 and NFKBIA and the downregulated DEGs including AKT1, HLA antigen genes (HLA-DMA, HLA-DRA, HLA-DQB1, and CD74/HLADG), and IFN-related genes (such as ISG15, IFIT1, and IFI6) were the potential targets for the management of immunotherapies for sepsis-induced immunosuppression. The gene discussed is HLA-DQB1; the disease is Sepsis.