TNF and inflammatory bowel disease: The DEGs in the red cluster were associated with GO biological processes including “GO:0006096: glycolytic process,” “GO:0006954: inflammatory response,” “GO:0006809: nitric oxide biosynthetic process,” and “GO:0042542: response to hydrogen peroxide” (supplementary table S3, http://links.lww.com/MD/F952), and were involved in the KEGG pathways including “hsa01130: Biosynthesis of antibiotics,” “hsa00010: Glycolysis/Gluconeogenesis,” “hsa04668: TNF signaling pathway,” “hsa04621: NOD-like receptor signaling pathway,” and “hsa05321: Inflammatory bowel disease” (Fig. 2B).