PCR confirmed the significant upregulation of the genes including ANXA1, SIPR1, EDN1, and RSAD2 in the neutrophils samples from patients with sepsis-induced immunosuppression (at 3–4 days and/or 6–8 days post sepsis shock) compared with controls (P < .05; Fig. 5). The gene discussed is EDN1; the disease is Sepsis.