CD28 and Sepsis: Individuals with SS are characterized by severe disturbed immune homeostasis or suppressive immunophenotype.[6,7] Immunosuppression in sepsis patients with Candida infection is characterized by T cell exhaustion and a concomitant decrease in positive co-stimulatory molecules, including CD28 and major histocompatibility complex, class II (HLA)-antigens.[7,8] Immunosuppression intensity and duration of sepsis are positively associated with mortality and infections.[9]