NFKB1 and Immunodeficiency: They also showed that IL-10 did not influence the production of IFN-γ or TNF-α in NK cells.[50] Unlike IL-10, IL-15 protects neutrophils from apoptosis via activating the NF-κB signaling and enhances the functions of multiple innate immune cells in patients with human immunodeficiency.[55,56] It also increases the secretion of macrophages cytokines, the levels of IFNγ, and the percentage of NK cells, DCs, and CD8+ T cells[30,57,58] (Fig. 6).