The results indicated that exogenous ANXA4 was mainly modified by SUMO1, SUMO2 and SUMO3; however, the transfection of an HA-SUMO plasmid did not upregulate ANXA4 expression (Figure 4B) or influence the membrane-cytoplasm translocation of ANXA4 in CRC cells (data not shown). This evidence concerns the gene ANXA4 and colorectal carcinoma.