Using Gene Expression Omnibus datasets (GEO) [GSE20916 (Poland), Skrzypczak Colorectal; GSE 8671 (Switzerland), and Sabates-Bellver Colon], we found that ANXA4 expression was significantly higher in colorectal cancer tissue than in the normal colonic mucosa (Figure 1A). This evidence concerns the gene ANXA4 and colorectal cancer.