Interestingly, while in Ang II-dependent hypertension we did not detect a significant reduction of blood pressure following empagliflozin administration, despite a significant increase of diuresis and natriuresis [26], in the experimental model of CSA nephropathy we observe that empagliflozin administration causes a significant decrease in blood pressure, which, however, remained higher than the control group values. The gene discussed is AGT; the disease is hypertensive disorder.