FOLH1 and Familial prostate cancer: Prostate-specific membrane antigen (PSMA, also known as glutamate carboxypeptidase II, N-acetyl-L-aspartyl-L-glutamate peptidase I, and folate hydrolase 1) is a type II transmembrane glycoprotein acting as carboxypeptidase, highly expressed in prostate- and prostate cancer tissue (Chang 2004; Meller et al. 2015; Horoszewicz et al. 1987).