RAB33B and infection: As shown in Fig 1A and 1B, both endogenous and mRFP-tagged Rab6A and Rab33B were detected in a significant fraction of LCVs, and the recruitment of these Rabs to the LCVs are increasing at 2 h post infection, corresponding to the time when ER protein calnexin starts to accumulate on the LCV [26,27].