Another immunohistochemical study was performed in 380 adenomas for differences in molecular Ki-67, COX-2, TGFβRI, EGFR, β-catenin, cyclin D1, c-MYC and TUNEL (apoptosis) mutations of proximal and distal adenomas, which may contribute for cancer heterogeneity between the two topographies. The gene discussed is CCND1; the disease is adenoma.