MERTK and Nager acrofacial dysostosis: Further, mutations in tyrosine kinases related to MeRTK, required for astroglial engulfment of neuronal debris in vertebrates (Chung et al., 2013), also seem to not be required for AMsh engulfment of AFD–NRE (Figure 4—figure supplement 1A; Popovici et al., 1999).