H3K27me3 inhibitor DZNep effectively reduces PRC2‐EZH2‐modified H3K27me3 levels in the promoters of WNT1, WNT6 and WNT10a, thereby activating the WNT/β‐catenin signal, and increases bone formation in osteoporosis mice.68 This evidence concerns the gene EZH2 and osteoporosis.