It might be that children with early transient and persistent eczema have skin conditions (i.e., pH level, natural moisturizing factor and filaggrin gene mutations) more suitable for S. aureus overgrowth, increased contact with parents due to frequent comforting, S. aureus contaminated topical ointments and/or specific household conditions promoting S. aureus colonization (i.e., less frequent handwashing, shared towel use and shared bedrooms).39, 40, 41, 42. The gene discussed is FLG; the disease is Eczematoid dermatitis.