Downregulation of EMT-TFs upon DOC2B overexpression may be linked to Ras-MAPK, Wnt/β-catenin and PI3K-AKT pathways as these pathways have shown to activate EMT–TFs leading to downregulation of CDH1 along with simultaneous activation of CDH2 and VIM resulting in invasion and metastasis in numerous cancers (Hong et al. 2011; Larue and Bellacosa 2005). This evidence concerns the gene CDH2 and cancer.