AKT1 and neoplasm: Activated CTNNB1, through signalling events initiated by phosphorylation of AKT, translocates to the nucleus and initiates the expression of downstream targets such as CCND1 and CCNE, TWIST, SNAIL, MMPs, C-MYC, and several others rendering tumor cells more invasive (He et al. 2009; Karim et al. 2004; Klaus and Birchmeier 2008; Yook et al. 2005).