IGFBP1 and diabetes mellitus: In the ‘Woroniecka Diabetes Glom’ dataset [17], IGFBP-1, -2 and -5 were downregulated in the glomeruli of diabetic individuals, with IGFBP-1 being the most highly downregulated gene (−3.83 fold change, p = 9.6 × 10−4) (Fig. 1a–f).