Increased intracellular pH in cancer cells is maintained by the enhanced activity of plasma membrane ion transporters and pH regulators such as Na+-driven HCO3 exchangers,35 Na+–H+ exchangers 1 (NHE1),36 monocarboxylate transporter 1 and 4 (MCT1 and MCT4),37 and carbonic anhydrases (Cas).38 Here, SLC16A1 is linked to cancer.