Additionally, increased reactive microglia in PD patients52 and increased concentrations of inflammatory cytokines, such as interleukin 6 (IL-6) and interleukin 1 beta (IL1-β) in CSF from PD patients,53 could be linked to degraded BBB tight junction proteins and increased BBB permeability.54 The gene discussed is IL1B; the disease is Parkinson disease.