TCF4 and colorectal cancer: Furthermore, key Wnt signaling components, such as TCF4, DVL3, and FZD7, and the β-catenin major transcriptional effector TCF7L2 are direct targets of YTHDF1, and YTHDF1 can activate the Wnt/β-catenin signaling pathway by regulating these targeted genes and then promote intestinal stemness and tumorigenesis of colorectal cancer 49.