The top 10 mutated genes in melanoma were TTN (72%), MUC16 (67%), DNAH5 (49%), PCLO (44%), LRP1B (38%), ANK3 (32%), DNAH7 (32%), ADGRV1 (35%), RP1 (33%), and BRAF (51%) (Figure 2F). The gene discussed is PCLO; the disease is melanoma.