Previous reports have found that SCARA5 is downregulated in several types of malignant tumors owing to SCARA5 promoter methylation, to investigate whether the decreased SCARA5 expression is correlated with promoter hypermethylation, DNA samples from 36 GC and 16 non-cancerous gastric mucosa tissues were subjected to MSP assay to detect the methylation frequency of CpG island within SCARA5 gene promoter. Here, SCARA5 is linked to cancer.