Moreover, endometriosis was found to be associated with amplification of epidermal growth factor receptor (EGFR) gene and the activation of EGFR plays a critical role in cell proliferation, apoptosis, angiogenesis, and metastasis 16, thus it is necessary to identify whether the amplification of EGFR can trigger the progression from endometriosis to carcinoma. The gene discussed is EGFR; the disease is endometriosis.