EGFR and carcinoma: Moreover, endometriosis was found to be associated with amplification of epidermal growth factor receptor (EGFR) gene and the activation of EGFR plays a critical role in cell proliferation, apoptosis, angiogenesis, and metastasis 16, thus it is necessary to identify whether the amplification of EGFR can trigger the progression from endometriosis to carcinoma.