In addition, KEGG analysis enriched the up-regulated RBPs in Regulation of actin cytoskeleton, Cell cycle, virus infection like human papillomavirus (HPV), human immunodeficiency virus (HIV), etc., and cancer metabolic processes including proteoglycans in cancer, HIF1 signaling pathway, Glycolysis/Gluconeogenesis, Central carbon metabolism in cancer, etc. (Figure S2B). The gene discussed is HIF1A; the disease is cancer.