Previous studies have reported that the expression of LEPR 42, PFKM 43, 44, PGK1 45, 46, CYP19A1 47, 48, SLC20A1 49, and ZC3H12D 50 were associated with tumorigenesis and progression in various tumor types, which support the further identification and exploring in tongue cancer. The gene discussed is CYP19A1; the disease is tongue cancer.