TM4SF1 and cancer: Using this analysis, ranking the output by the mean of the JACKS score at 19 days minus the mean of the JACKS score at 4 h, the top two genes were Lrrn4cl and Tm4sf19. Tm4sf19 (transmembrane 4L six family member 19, also known as Octm4) is a member of the four-transmembrane L6 superfamily, which includes TM4SF1, whose overexpression in many cancers is associated with poor prognosis, and has roles in proliferation, invasion, and metastasis24.