In melanoma patients, high expression of LRRN4CL significantly correlated with worse outcome, in both the TCGA dataset (Cox Log-rank P = 0.0008, age- and sex-adjusted; Fig. 5c), and the AVAST-M dataset15 (Cox Log-rank P = 0.048 [univariate analyses], Fig. 5d and Supplementary Fig. 9a, respectively). Here, LRRN4CL is linked to melanoma.