LRRN4CL and central nervous system cancer: Analysis of the TCGA datasets also showed that high expression of LRRN4CL correlated with worse outcome in low-grade glioma, renal clear cell carcinoma and ovarian carcinoma (univariate analysis, Log-rank P = 1.17 × 10−6, 0.027 and 0.048, respectively; Supplementary Fig. 9c–e).