LRRN4CL and neoplasm: As upregulated LRRN4CL expression only provided an advantage to metastatic tumour cells in the lung, with no phenotypic effect observed in vitro, we performed RNAseq of human A375 melanoma cells expressing LRRN4CL (A375_LRNmCherry cells; ‘L’) that had been colonising the lung for 21 days.