The AUC values of ITGAM, CAMP, TYROBP and ICAM1 were 0.714 (95% CI 0.666–0.762; P < 0.001) with a sensitivity of 74.3% and a specificity of 76.2%; 0.897 (95% CI 0.865–0.928; P < 0.001) with a sensitivity of 84.2% and a specificity of 91.1%; 0.761 (95% CI 0.716–0.807; P < 0.001) with a sensitivity of 77.1% and a specificity of 79.7% and 0.848 (95% CI 0.811–0.885; P < 0.001) with a sensitivity of 83.3% and a specificity of 86.7% for prediction of CAD risk, respectively. Here, ICAM1 is linked to coronary artery disorder.